PROCEDURE OPTIMIZATION FOR DETERMINATION OF PERFLUOROOCTANE SULFONIC ACID (PFOS) AND PERFLUOROOCTANOIC ACID (PFOA) IN PAPER – BASED FOOD PACKAGING SAMPLES

Ha Thi Thu Hoai; Nguyen Trong Nghia; Nguyen Thi Quynh Hoa

Ha Thi Thu Hoai Hai Duong Department of Science and Technology
Nguyen Trong Nghia Faculty of Chemical and Environmental Technology, Hung Yen University of Technology and Education
Nguyen Thi Quynh Hoa Faculty of Chemical and Environmental Technology, Hung Yen University of Technology and Education

Keywords: Perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), paper-based food packaging, LC-MS/MS

Abstract

In this study, a method for simultaneous determination of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) in paper-based food packaging was validated by liquid chromatography–tandem mass spectrometry (LC-MS/MS). The paper samples were extracted with ethanol/water (1:1, v/v) mixture at 70 °C for 2 hours by using an incubator shake, filters before LC-MS/MS analysis. Limit of detection (LOD) and limit of quantification(LOQ) of both PFOS and PFOA was 0.2 and 0.02 ng/mL, method detection limit (MDL) and method quantification limit (MQL) of both PFOS and PFOA was 0.11 and 0.28 ng/g, respectively. The mean recovery for PFOS was 76 %, PFOA was 113 %, and repeatability (RSD) was 0.11 % and 0.22 %, respectively. The method was applied to analyze nine paper samples, however, PFOA and PFOS were not detected in any of these samples.

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